The Automotive tire sealant formula uses fibers and particles that are designed to pass through the more narrow opening of snap-in style TPMS sensors.
The Off-Road tire sealant formula uses a different combination of fibers and particles to seal larger punctures which are more likely to clog TPMS sensors. This is why it is important to use the Automotive tire sealant for TPMS enabled vehicles. The Automotive tire sealant is designed and tested to work with TPMS sensors (more info here).